Como as células cancerosas iludem o impacto da privação hormonal

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Há progressos no entendimento de como as células cancerosas iludem o tratamento hormonal. Conhecendo o mecanismo será mais fácil bloqueá-lo. George Kulik, pesquisador da Wake Forest University School of Medicine afirma que as células cancerosas usam três caminhos para desativar uma proteína, BAD, que provoca a morte das délulas. Essa descoberta abre muitos caminhos, como bloquear os canais, impedir a mensagem, proteger a proteína e muitos outros

Prostate cancer cells smartly defy death

"”The normal response of prostate cells when male hormones are blocked is cell death,” said George Kulik, assistant professor of cancer biology and senior researcher at Wake Forest University School of Medicine. “The cancer cells find a way to resist the treatment and we wanted to discover the mechanism.”

Researchers have discovered the canny and shrewd way prostate cancer cells manage to defy death and become resistant to hormone treatment. The prostate cancer cells are using three separate pathways to send signals to cancer cells by inactivating a protein, BAD, meant to cause cell death.

If animal and human studies further prove what the researchers have discovered, new drug therapies could be developed to keep BAD active and doing its job in helping to destroy prostate cancer cells.

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